The HOXB4 homeoprotein improves ex vivo generation of functional human NK-cell progenitors
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چکیده
منابع مشابه
The HOXB4 Homeoprotein Promotes the Ex Vivo Enrichment of Functional Human Embryonic Stem Cell-Derived NK Cells
Human embryonic stem cells (hESCs) can be induced to differentiate into blood cells using either co-culture with stromal cells or following human embryoid bodies (hEBs) formation. It is now well established that the HOXB4 homeoprotein promotes the expansion of human adult hematopoietic stem cells (HSCs) but also myeloid and lymphoid progenitors. However, the role of HOXB4 in the development of ...
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Hox transcription factors have emerged as important regulators of primitive hematopoietic cell proliferation and differentiation. In particular, HOXB4 appears to be a strong positive regulator of hematopoietic stem cell (HSC) self-renewal. Here we demonstrate the potency of HOXB4 to enable high-level ex vivo HSC expansion. Cultures of nontransduced or GFP-transduced murine bone marrow cells exp...
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INCE ITS INCEPTION as a medical specialty, hematolS ogy has had the unique perspective of considering therapeutics to include not only small molecular weight pharmaceuticals, but also cells themselves. Recognizing the complexity of the functions performed by the blood cells, hematologists have long understood that our best chance of harnessing the power of these cells for oxygen transport, repa...
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Background and Aim: Tooth discoloration induced by endodontic materials is a common finding which can impair the aesthetic outcome. The aim of this study was to compare the coronal discoloration induced by Well-Root ST and AH26 root canal sealers by using the Easyshade® colorimeter. Materials and Methods: Forty-five intact maxillary central incisors were involved in this experimental study. Th...
متن کاملHOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4.
BACKGROUND Expansion of hematopoietic stem cells represents an important objective for improving cell and gene therapy protocols. Retroviral transduction of the HoxB4 homeogene in mouse and human hematopoietic stem cells and hematopoietic progenitors is known to promote the cells' expansion. A safer approach consists in transferring homeobox proteins into hematopoietic stem cells taking advanta...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2007
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2404725